Depending on the type of the clog you have in the main sewer line, using just an auger or enzymes will not unclog your sewer line. You will need an electrical sewer snake to unclog your main sewer line. The sewer line gets clogged most of the time because of tree roots and grease build up and in most cases the sewer clog is further down the line and requires an electrical snake to do a proper cleaning.
To avoid getting sewer clogs, it is recommended to have your main sewer cleaning once a year as a preventative maintenance. Sewer clogs can cause a flood in your basement and should be taken seriously.